Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2971657 | 0.98 | KDM4E (0.57) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL11156898 | 0.90 | KDM4E (0.56) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL20804356 | 0.88 | CYP1A2 (0.71) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL29992091 | 0.88 | CYP1A2 (0.71) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL1333260 | 0.88 | CYP1A2 (0.71) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL1331974 | 0.88 | CYP1A2 (0.71) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL30141847 | 0.88 | CYP1A2 (0.71) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL25434058 | 0.83 | CYP2C19 (0.62) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL1306448 | 0.83 | CYP1A2 (0.58) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 | |
| SCHEMBL27604951 | 0.83 | CYP1A2 (0.58) | ALDH1A1KDM4ENPSR1HRH1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-05-25 | — | — | US | disclosed |
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-05-25 | — | — | US | disclosed |
| US-8623873-B2 | Substituted piperazines as CB1 antagonists | INTERVET INC. (US) | 2014-01-07 | — | — | US | disclosed |
| EP-1819684-B1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | INTERVET INT BV (NL) | 2013-08-07 | — | — | EP | disclosed |
| US-20130072468-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | GILBERT ERIC J (US) | 2013-03-21 | — | — | US | disclosed |
| EP-2548874-A2 | Substituted piperazines as CB1 antagonists | Intervet International B.V. (NL) | 2013-01-23 | — | — | EP | disclosed |
| US-8236805-B2 | Substituted piperazines as CB1 antagonists | INTERVET INC. (US) | 2012-08-07 | — | — | US | disclosed |
| US-20100286160-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | INTERVET INC. | 2010-11-11 | — | — | US | disclosed |
| US-20100249144-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | INTERVET INTERNATIONAL B.V. (NL) | 2010-09-30 | — | — | US | disclosed |
| US-7700597-B2 | Substituted piperazines as CB1 antagonists | SCHERING CORPORATION (US) | 2010-04-20 | — | — | US | disclosed |
| EP-2170847-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | Intervet International BV (NL) | 2010-04-07 | — | — | EP | disclosed |
| US-20100029607-A1 | Substituted Piperazines as CB1 Antagonists | SCHERING CORPORATION | 2010-02-04 | — | — | US | disclosed |
| US-20090105208-A1 | Substituted Piperazines as CB1 Antagonists | SCHERING CORPORATION | 2009-04-23 | — | — | US | disclosed |
| WO-2009005671-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009005645-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009005646-A2 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| EP-1819684-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2007-08-22 | — | — | EP | disclosed |
| US-20060241121-A1 | Substituted piperazines as CB1 antagonists | MERCK SHARP & DOHME CORP. | 2006-10-26 | — | — | US | disclosed |
| WO-2006060461-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | SCHERING CORPORATION (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2003008559-A2 | NOVEL ANALOGS OF CHOLINE FOR NEUROPROTECTION AND COGNITIVE ENHANCEMENT IN NEURODEGENERATIVE DISORDERS | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) | 2003-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286160-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | CNR1, CNR2, GPR119 | ALDH1A1 1520/4885KDM4E 2473/4885NPSR1 9/4885 |
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | HNMT, TYR, PNMT | ALDH1A1 2859/4885KDM4E 418/4885NPSR1 2460/4885 |
| US-20060241121-A1 | Substituted piperazines as CB1 antagonists | CNR1, CNR2, GPR119 | ALDH1A1 1520/4885KDM4E 2473/4885NPSR1 9/4885 |
| US-20130072468-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | CNR1, CNR2, GPR119 | ALDH1A1 1520/4885KDM4E 2473/4885NPSR1 9/4885 |
| US-20100029607-A1 | Substituted Piperazines as CB1 Antagonists | CNR1, CNR2, GPR119 | ALDH1A1 1520/4885KDM4E 2473/4885NPSR1 9/4885 |
| US-20090105208-A1 | Substituted Piperazines as CB1 Antagonists | CNR1, CNR2, GPR119 | ALDH1A1 1520/4885KDM4E 2473/4885NPSR1 9/4885 |
| US-20100249144-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | CNR1, CNR2, GPR119 | ALDH1A1 1510/4885KDM4E 2453/4885NPSR1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.