Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 4/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL28246456 | 0.89 | ARG1 (0.47) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| Cadaverine Tartrate SCHEMBL28180970 | 0.88 | ARG1 (0.44) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| Alanine SCHEMBL31346583 | 0.87 | SMN1; SMN2 (0.47) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| SCHEMBL28096522 | 0.83 | ALDH1A1 (0.54) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| D-Glutamate SCHEMBL28571062 | 0.83 | ARG1 (0.51) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| Bromide SCHEMBL28096069 | 0.82 | ALDH1A1 (0.53) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| SCHEMBL28247432 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| SCHEMBL31346586 | 0.79 | ALDH1A1 (0.49) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| Sulfuric Acid SCHEMBL29275071 | 0.77 | TLR8 (0.49) | SMN1; SMN2ARG1ALDH1A1POLBKMT2A | |
| SCHEMBL30833253 | 0.75 | TLR8 (0.42) | SMN1; SMN2ALDH1A1POLBKMT2ATLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107353252-A | A kind of ionic liquid with carboxylic acid and its preparation method and application | 辽宁大学 | 2017-11-17 | — | — | CN | disclosed |