Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL926052 | 0.83 | ALDH1A1 (0.50) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL28182976 | 0.81 | FLT3 (0.44) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL28950139 | 0.78 | DYRK1A (0.61) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL18041689 | 0.78 | TGFBR1 (0.61) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| Alcohol SCHEMBL11561027 | 0.77 | ALDH1A1 (0.44) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL28182986 | 0.74 | TGFBR1 (0.47) | MAPTKDM4EKMT2AMEN1TGFBR1 | |
| SCHEMBL28182113 | 0.71 | TGFBR1 (0.51) | TGFBR1MAPK14 | |
| SCHEMBL622115 | 0.71 | KDM4E (0.56) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL29550130 | 0.71 | KDM4E (0.56) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4035268 | 0.69 | TGFBR1 (0.60) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107406412-A | TGF beta inhibitors | 里格尔药品股份有限公司 | 2017-11-28 | — | — | CN | claimed |
| CN-107406412-A | TGF beta inhibitors | 里格尔药品股份有限公司 | 2017-11-28 | — | — | CN | disclosed |