Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2818483 | 1.00 | HTT (0.51) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL2820965 | 0.94 | TAS1R3 (0.44) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL803565 | 0.94 | TAS1R3 (0.44) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL2822028 | 0.89 | CYP1A2 (0.59) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL484507 | 0.86 | KCNA5 (0.44) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL484509 | 0.86 | KCNA5 (0.44) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL785752 | 0.85 | PDE4A (0.47) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL785751 | 0.85 | PDE4A (0.47) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL13131208 | 0.83 | KCNA5 (0.47) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 | |
| SCHEMBL15226408 | 0.83 | KCNA5 (0.47) | HTTCYP1A2KCNA5ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | HTT 3621/4885CYP1A2 3400/4885KCNA5 237/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | HTT 3621/4885CYP1A2 3400/4885KCNA5 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.