SCHEMBL28186274

SCHEMBL28186274

Cc1nccn1-c1ccc(C(=O)O)cc1.[Zn]

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.63
NR4A2 P43354 1/20 0.63
ALDH1A1 P00352 4/20 0.57
PDE4A P27815 2/20 0.57
PDE4B Q07343 2/20 0.57
PDE4C Q08493 2/20 0.57
PDE4D Q08499 2/20 0.57
PDE3B Q13370 2/20 0.52
PDE3A Q14432 2/20 0.52
CYP3A4 P08684 3/20 0.49
CYP2D6 P10635 2/20 0.49
CYP1A2 P05177 1/20 0.49
CYP19A1 P11511 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
ADH5 P11766 2/20 0.48
CYP2E1 P05181 1/20 0.47
CYP2A6 P11509 1/20 0.47
KDM4E B2RXH2 2/20 0.47
POLB P06746 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL326869 0.98 NR4A1 (0.65) NR4A1NR4A2ALDH1A1PDE4APDE4B
SCHEMBL30831804 0.86 PDE4A (0.68) NR4A1NR4A2ALDH1A1PDE4APDE4B
SCHEMBL28100871 0.85 ALDH1A1 (0.58) NR4A1NR4A2ALDH1A1PDE4APDE4B
SCHEMBL31589965 0.84 NR4A1 (0.64) NR4A1NR4A2ALDH1A1PDE4APDE4B
SCHEMBL10201831 0.84 RXRA (0.57) NR4A1NR4A2CYP3A4CYP2D6CYP1A2
SCHEMBL30558759 0.82 ALDH1A1 (0.71) NR4A1NR4A2ALDH1A1PDE4APDE4B
SCHEMBL28427931 0.81 NR4A1 (0.47) NR4A1NR4A2ALDH1A1PDE4APDE4B
SCHEMBL10476781 0.81 NR4A1 (0.60) NR4A1NR4A2ALDH1A1PDE4APDE4B
SCHEMBL327622 0.81 PDE4A (0.54) NR4A1NR4A2ALDH1A1PDE4APDE4B
SCHEMBL17116879 0.81 PDE4A (0.56) NR4A1NR4A2ALDH1A1PDE4APDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107286099-A Zn complex and its application that one kind is constructed based on 4 (2 methylimidazole) benzoic acid 陕西理工学院 2017-10-24 CN disclosed