Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926124 | 0.91 | KMT2A (0.42) | ALDH1A1MAPTMAPK1MEN1GAA | |
| SCHEMBL17659019 | 0.91 | KMT2A (0.42) | ALDH1A1MAPTMAPK1MEN1GAA | |
| SCHEMBL17659703 | 0.89 | MEN1 (0.40) | HTR5AALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL11759243 | 0.87 | HTR5A (0.57) | HTR5ADRD2DRD3DRD1HTR2A | |
| SCHEMBL29236372 | 0.81 | GAA (0.41) | HTR5ADRD2DRD3DRD1HTR2A | |
| SCHEMBL17659681 | 0.81 | GAA (0.41) | HTR5ADRD2DRD3DRD1HTR2A | |
| SCHEMBL19381507 | 0.80 | ALDH1A1 (0.59) | HTR5ADRD2DRD3DRD1HTR2A | |
| SCHEMBL19381512 | 0.78 | ALDH1A1 (0.57) | HTR5ADRD2DRD3DRD1HTR2A | |
| SCHEMBL11441903 | 0.76 | ALDH1A1 (0.46) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL19381288 | 0.74 | ALDH1A1 (0.61) | ALDH1A1MAPTSMN1; SMN2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107443701-B | The manufacturing method of laminated resin body | 住友化学株式会社 | 2019-09-03 | — | — | CN | disclosed |
| CN-109219517-A | Laminated resin body with protective film | 住友化学株式会社 | 2019-01-15 | — | — | CN | disclosed |
| CN-109153245-A | Laminated resin body, display device and polarizer | 住友化学株式会社 | 2019-01-04 | — | — | CN | disclosed |
| CN-107443701-A | The manufacture method of laminated resin body | 住友化学株式会社 | 2017-12-08 | — | — | CN | disclosed |
| CN-107443700-A | The manufacture method of laminated resin body | 住友化学株式会社 | 2017-12-08 | — | — | CN | disclosed |