Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28001859 | 0.83 | HRH3 (0.48) | KDM1AMAOA | |
| SCHEMBL4392356 | 0.81 | UTS2R (0.49) | RIPK1UTS2RCYP2D6 | |
| SCHEMBL23123430 | 0.81 | RIPK1 (0.50) | RIPK1UTS2R | |
| SCHEMBL5747606 | 0.77 | RIPK1 (0.50) | RIPK1ALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL5746647 | 0.77 | RIPK1 (0.50) | RIPK1ALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL6310814 | 0.77 | RIPK1 (0.50) | RIPK1ALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL5746649 | 0.77 | RIPK1 (0.50) | RIPK1ALDH1A1SMN1; SMN2DPP4DPP8 | |
| SCHEMBL1847627 | 0.76 | RIPK1 (0.69) | RIPK1HSP90AA1HSP90AB1 | |
| SCHEMBL1853141 | 0.76 | RIPK1 (0.69) | RIPK1HSP90AA1HSP90AB1 | |
| SCHEMBL17558248 | 0.76 | RIPK1 (0.69) | RIPK1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105102456-B | Azaquinazoline inhibitors of atypical protein kinase C | 癌症研究技术有限公司 | 2017-11-14 | — | — | CN | disclosed |
| CN-105102456-A | Azaquinazoline inhibitors of atypical protein kinase C | IGNYTA INC | 2015-11-25 | — | — | CN | disclosed |