SCHEMBL1853141

SCHEMBL1853141

O=C(O)N1CCC[C@@H]1c1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 3/20 0.69
HSP90AA1 P07900 1/20 0.58
HSP90AB1 P08238 1/20 0.58
EPHX2 P34913 2/20 0.56
HSD11B1 P28845 2/20 0.56
SCD5 Q86SK9 5/20 0.55
SCD O00767 3/20 0.55
CHRNB2 P17787 1/20 0.55
CHRNB4 P30926 1/20 0.55
CHRNA3 P32297 1/20 0.55
CHRNA7 P36544 1/20 0.55
CHRNA4 P43681 1/20 0.55
CCNC P24863 1/20 0.49
CDK8 P49336 1/20 0.49
PPID Q08752 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17558248 1.00 RIPK1 (0.69) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
SCHEMBL1847627 1.00 RIPK1 (0.69) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
SCHEMBL216202 0.95 RIPK1 (0.62) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
SCHEMBL27574946 0.95 RIPK1 (0.62) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
SCHEMBL27574934 0.95 RIPK1 (0.62) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
Water SCHEMBL27700791 0.93 RIPK1 (0.60) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
SCHEMBL311128 0.90 RIPK1 (0.57) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
SCHEMBL17026995 0.89 RIPK1 (0.67) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
SCHEMBL3062584 0.87 RIPK1 (0.67) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1
SCHEMBL27659813 0.86 RIPK1 (0.57) RIPK1HSP90AA1HSP90AB1EPHX2HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10730912-B2 Template-fixed peptidomimetics with antimicrobial activity POLYPHOR LTD. (CH) 2020-08-04 US disclosed
US-10100084-B2 Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity POLYPHOR LTD. (CH) 2018-10-16 US disclosed
US-10000535-B2 Template-fixed peptidomimetics POLYPHOR LTD. (CH) 2018-06-19 US disclosed
US-20170369523-A1 TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE MODULATORS OF TRANSCRIPTION FACTORS AND COACTIVATORS POLYPHOR AG (CH) 2017-12-28 US disclosed
US-20170107259-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY POLYPHOR LTD. (CH) 2017-04-20 US disclosed
US-9596852-B2 Template-fixed peptidomimetics with antimicrobial activity POLYPHOR LTD. (CH) 2017-03-21 US disclosed
US-9538752-B2 Template-fixed peptidomimetics with antimicrobial activity POLYPHOR LTD. (CH) 2017-01-10 US disclosed
US-9521846-B2 Template-fixed peptidomimetics with antimicrobial activity POLYPHOR LTD. (CH) 2016-12-20 US disclosed
US-9518092-B2 Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity POLYPHOR LTD. (CH) 2016-12-13 US disclosed
US-20160333051-A1 TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY POLYPHOR LTD (CH) 2016-11-17 US disclosed
EP-1549670-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY Polyphor Ltd. (CH) 2005-07-06 EP disclosed
EP-1532164-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY Polyphor Ltd. (CH) 2005-05-25 EP disclosed
WO-2004096839-A1 TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY POLYPHOR AG (CH) 2004-11-11 WO disclosed
WO-2004096840-A1 TEMPLATE- FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY POLYPHOR AG (CH) 2004-11-11 WO disclosed
EP-1458747-A1 TEMPLATE-FIXED PEPTIDOMIMETICS AS INHIBITORS OF SERINE PROTEASES Polyphor Ltd. (CH) 2004-09-22 EP disclosed
WO-2004033489-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY POLYPHOR LTD. (CH) 2004-04-22 WO disclosed
WO-2004018503-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIBACTERIAL ACTIVITY POLYPHOR LTD. (CH) 2004-03-04 WO disclosed
EP-1363934-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY Polyphor Ltd. (CH) 2003-11-26 EP disclosed
WO-2003054000-A1 TEMPLATE-FIXED PEPTIDOMIMETICSAS INHIBITORS OF SERINE PROTEASES POLYPHOR LTD. (CH) 2003-07-03 WO disclosed
WO-2002070547-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY POLYPHOR LTD. (CH) 2002-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10100084-B2 Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity CTSG, CTRL, PREP RIPK1 4436/4885HSP90AA1 2654/4885HSP90AB1 2226/4885
US-20160333051-A1 TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY CTSG, CTRL, PREP RIPK1 4436/4885HSP90AA1 2654/4885HSP90AB1 2226/4885
US-20170107259-A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY POLL, POLM, POLR1C RIPK1 4177/4885HSP90AA1 2436/4885HSP90AB1 2357/4885
US-10000535-B2 Template-fixed peptidomimetics CCR10, CXCR3, CCR5 RIPK1 1823/4885HSP90AA1 3699/4885HSP90AB1 4047/4885
US-10730912-B2 Template-fixed peptidomimetics with antimicrobial activity POLL, POLM, POLR1C RIPK1 4129/4885HSP90AA1 2469/4885HSP90AB1 2408/4885
US-20170369523-A1 TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS THAT ARE LIGANDS FOR G-PROTEIN-COUPLED RECEPTORS (GPCRS) AND ARE MODULATORS OF TRANSCRIPTION FACTORS AND COACTIVATORS NCOA1, NCOA2, NCOR1 RIPK1 2323/4885HSP90AA1 3661/4885HSP90AB1 4191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.