Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 6/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28188380 | 0.83 | RIPK1 (0.47) | KDM1AMAOA | |
| SCHEMBL13196796 | 0.70 | HRH3 (0.57) | HRH3PARP10PARP1KDM1AMAOA | |
| SCHEMBL2801398 | 0.70 | HRH3 (0.57) | HRH3PARP10PARP1KDM1AMAOA | |
| SCHEMBL2801393 | 0.70 | HRH3 (0.57) | HRH3PARP10PARP1KDM1AMAOA | |
| SCHEMBL28330716 | 0.70 | KMO (0.65) | HRH3PARP1OPRM1OPRD1 | |
| SCHEMBL29503161 | 0.70 | KMO (0.65) | HRH3PARP1OPRM1OPRD1 | |
| SCHEMBL1036815 | 0.69 | PARP1 (0.64) | HRH3PARP14PARP1OPRM1OPRD1 | |
| SCHEMBL7353596 | 0.68 | DRD3 (0.57) | PARP14PARP10PARP1TNKSOPRM1 | |
| SCHEMBL13070743 | 0.68 | PARP1 (0.58) | HRH3PARP1KDM1AOPRM1OPRD1 | |
| SCHEMBL28089302 | 0.68 | PARP14 (0.53) | PARP14PARP10PARP1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104271579-A | L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists | NOVARTIS AG | 2015-01-07 | — | — | CN | disclosed |