SCHEMBL28188488

SCHEMBL28188488

C=CCNC1=CC(=O)C(SCC=C)=CC1=O

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11666449 0.68 ALDH1A1 (0.32) MEN1CYP3A4KMT2A
SCHEMBL28880080 0.68 CA12 (0.34) MEN1CYP1A2CYP3A4CYP2C19KMT2A
SCHEMBL4784115 0.66 PTPRC (0.50) MEN1CYP3A4KMT2A
SCHEMBL7695989 0.65
SCHEMBL2531942 0.62 MAOA (0.58) MEN1CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL28880084 0.62 HPGD (0.35) CYP1A2CYP3A4CYP2C19KMT2A
SCHEMBL30587670 0.62 MAOA (0.58) MEN1CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL10883313 0.60 KMT2A (0.49) MEN1CYP1A2CYP3A4CYP2D6KMT2A
SCHEMBL3785939 0.60 ALDH1A1 (0.34) MEN1KMT2A
SCHEMBL20567610 0.60 ALDH1A1 (0.37) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106146367-B Allyl sulfenyl amino 1,4-benzoquinone class compound, it is prepared and application 北京大学 2017-12-26 CN claimed
CN-106146367-A Allyl sulfenyl amino 1,4-benzoquinone compounds, its preparation and application 北京大学 2016-11-23 CN claimed