Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 11/20 | 0.46 |
| ▸ | S100A4 | P26447 | 5/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.43 |
| ▸ | CDC25A | P30304 | 2/20 | 0.43 |
| ▸ | CDC25B | P30305 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 2/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657692 | 0.75 | CDC25B (0.56) | PTPRCSOAT1S100A4MAP2K7CDC25A | |
| SCHEMBL4629512 | 0.75 | S100A4 (0.76) | SOAT1S100A4MAP2K7CDC25ACDC25B | |
| SCHEMBL10917197 | 0.71 | SOAT1 (0.66) | SOAT1S100A4MAP2K7CDC25ACDC25B | |
| SCHEMBL4848419 | 0.71 | SOAT1 (0.78) | PTPRCSOAT1S100A4MAP2K7CDC25A | |
| SCHEMBL17445488 | 0.71 | CDC25B (0.78) | SOAT1S100A4MAP2K7CDC25ACDC25B | |
| SCHEMBL17445487 | 0.69 | SOAT1 (0.51) | SOAT1S100A4MAP2K7CDC25ACDC25B | |
| SCHEMBL1823503 | 0.69 | ALDH1A1 (0.60) | PTPRCS100A4MAP2K7CDC25ACDC25B | |
| SCHEMBL6233595 | 0.67 | PTPRC (1.00) | PTPRCCDC25ACDC25BKDM4EALDH1A1 | |
| SCHEMBL11666449 | 0.66 | ALDH1A1 (0.32) | KDM4EALDH1A1MAPTCYP3A4HPGD | |
| SCHEMBL4036050 | 0.66 | CASP3 (0.41) | PTPRCS100A4MAP2K7CDC25ACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008136642-A1 | NAPHTHOQUINONE-BASED PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF DISEASES INVOLVING OBESITY, DIABETES, METABOLIC SYNDROME, NEURO-DEGENERATIVE DISEASES AND MITOCHONDRIA DYSFUNCTION DISEASES | MAZENCE INC. (KR) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008066300-A1 | NAPHTHOQUINONE-BASED PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF DISEASES INVOLVING OBESITY, DIABETES, METABOLIC SYNDROME, NEURO-DEGENERATIVE DISEASES AND MITOCHONDRIA DYSFUNCTION DISEASES | MAZENCE INC. (KR) | 2008-06-05 | — | — | WO | disclosed |