Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL43101 | 0.95 | — | — | |
| Ammonia Solution, Strong SCHEMBL28482817 | 0.92 | — | — | |
| SCHEMBL27581592 | 0.92 | — | — | |
| Hydrochloric Acid SCHEMBL27707333 | 0.92 | — | — | |
| Methane SCHEMBL28113921 | 0.92 | — | — | |
| Hydrochloric Acid SCHEMBL2389399 | 0.92 | — | — | |
| Fluoride SCHEMBL7045998 | 0.90 | KMT2A (0.46) | KMT2AGAAALOX5TAAR1CHRM2 | |
| Formaldehyde SCHEMBL9312051 | 0.88 | — | — | |
| SCHEMBL29114910 | 0.86 | KMT2A (0.43) | KMT2AGAAALOX5TAAR1CHRM2 | |
| Furan SCHEMBL28992748 | 0.86 | KMT2A (0.43) | KMT2AGAAALOX5TAAR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303822-A1 | Thermoset Resin Compositions | HUNTSMAN ADVANCED MATERIALS AMERICAS LLC | 2023-09-28 | — | — | US | disclosed |
| EP-4200136-A1 | THERMOSET RESIN COMPOSITIONS | Huntsman Advanced Materials Americas LLC (US) | 2023-06-28 | — | — | EP | disclosed |
| US-20230091746-A1 | TOUGHENED THERMOSET RESIN COMPOSITIONS | HUNTSMAN ADVANCED MATERIALS AMERICAS LLC | 2023-03-23 | — | — | US | disclosed |
| EP-3265447-B1 | BENZOXAZINE LOW TEMPERATURE CURABLE COMPOSITION | HUNTSMAN ADVANCED MAT AMERICAS LLC (US) | 2023-03-01 | — | — | EP | disclosed |
| EP-4107212-A1 | TOUGHENED THERMOSET RESIN COMPOSITIONS | Huntsman Advanced Materials Americas LLC (US) | 2022-12-28 | — | — | EP | disclosed |
| WO-2022040125-A1 | THERMOSET RESIN COMPOSITIONS | HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) | 2022-02-24 | — | — | WO | disclosed |
| EP-2814802-B1 | MIXTURE OF BENZOXAZINE, EPOXY AND ANHYDRIDE | HUNTSMAN ADVANCED MAT AMERICAS LLC (US) | 2020-12-16 | — | — | EP | disclosed |
| US-20180030264-A1 | Benzoxazine Low Temperature Curable Composition | HUNTSMAN ADVANCED MATERIALS AMERICAS LLC | 2018-02-01 | — | — | US | disclosed |
| EP-3265447-A1 | BENZOXAZINE LOW TEMPERATURE CURABLE COMPOSITION | Huntsman Advanced Materials Americas LLC (US) | 2018-01-10 | — | — | EP | disclosed |
| US-9580577-B2 | Low dielectric loss thermoset resin system at high frequency for use in electrical components | HUNTSMAN INTERNATIONAL LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-20110152453-A1 | Benzoxazine Compounds Derivated From Phenolphtalein Having Flame-Retardant Properties And A Process For Their Preparation | HUNTSMAN ADVANCED MATERIALS AMERICAS INC. (US) | 2011-06-23 | — | — | US | disclosed |
| WO-2011041625-A1 | BENZOXAZINE BASED CURABLE COMPOSITION FOR COATINGS APPLICATIONS | HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) | 2011-04-07 | — | — | WO | disclosed |
| US-20100330287-A1 | HALOGEN-FREE BENZOXAZINE BASED CURABLE COMPOSITIONS FOR HIGH TG APPLICATIONS | HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) | 2010-12-30 | — | — | US | disclosed |
| EP-2254875-A2 | HALOGEN-FREE BENZOXAZINE BASED CURABLE COMPOSITIONS FOR HIGH TG APPLICATIONS | Huntsman Advanced Materials Americas LLC (US) | 2010-12-01 | — | — | EP | disclosed |
| WO-2010132772-A1 | LIQUID MONOBENZOXAZINE BASED RESIN SYSTEM | HUNTSMAN ADVANCED MATERIALS AMERICAS LLC (US) | 2010-11-18 | — | — | WO | disclosed |
| WO-2009137144-A2 | HALOGEN-FREE BENZOXAZINE BASED CURABLE COMPOSITIONS FOR HIGH TG APPLICATIONS | HUNTSMAN ADVANCED MATERIALS AMERICAS INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| US-20080302471-A1 | Composition Comprising Benzoxazine and Epoxy Resin | HUNTSMAN ADVANCED MATERIALS (SWITZERLAND) GMBH (CH) | 2008-12-11 | — | — | US | disclosed |
| EP-1797081-B1 | BENZOXAZINE COMPOUNDS DERIVATED FROM PHENOLPHTHALEIN HAVING FLAME-RETARDANT PROPERTIES AND A PROCESS FOR THEIR PREPARATION | HUNTSMAN ADV MAT SWITZERLAND (CH) | 2008-11-19 | — | — | EP | disclosed |
| EP-1871835-B1 | COMPOSITION COMPRISING BENZOXAZINE AND EPOXY RESIN | HUNTSMAN ADV MAT SWITZERLAND (CH) | 2008-08-13 | — | — | EP | disclosed |
| EP-1647576-A1 | Composition comprising benzoxazine and epoxy resin | Huntsman Advanced Materials (Switzerland) GmbH (CH) | 2006-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030264-A1 | Benzoxazine Low Temperature Curable Composition | CRYZ, PIEZO1, PSMD12 | KMT2A 1526/4885GAA 2501/4885ALOX5 61/4885 |
| US-20110152453-A1 | Benzoxazine Compounds Derivated From Phenolphtalein Having Flame-Retardant Properties And A Process For Their Preparation | HPD, PAH, BRPF3 | KMT2A 806/4885GAA 3518/4885ALOX5 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.