Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluquazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | TP53 | P04637 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluquazone SCHEMBL43464 | 0.93 | MAPT (0.58) | MAPTTP53LMNARXFP1 | |
| SCHEMBL11470963 | 0.85 | MAPT (0.57) | MAPTTP53LMNARXFP1KDM4E | |
| SCHEMBL11480424 | 0.85 | MAPT (0.57) | MAPTTP53LMNARXFP1KDM4E | |
| SCHEMBL11468011 | 0.84 | MAPT (0.56) | MAPTTP53LMNARXFP1KDM4E | |
| SCHEMBL11479018 | 0.84 | RXFP1 (0.51) | MAPTTP53LMNARXFP1KDM4E | |
| SCHEMBL11472800 | 0.83 | MAPT (0.59) | MAPTTP53LMNARXFP1KDM4E | |
| Fluquazone SCHEMBL28198204 | 0.83 | MAPT (0.52) | MAPTTP53LMNARXFP1 | |
| SCHEMBL11470918 | 0.83 | LMNA (0.56) | MAPTTP53LMNARXFP1KDM4E | |
| SCHEMBL11462119 | 0.82 | MAPT (0.56) | MAPTTP53LMNARXFP1 | |
| SCHEMBL11160129 | 0.82 | NR1I2 (0.50) | MAPTTP53LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107427546-A | Composition containing extract of discorea nipponica and its medicinal use | 师沛恩生技有限责任公司 | 2017-12-01 | — | — | CN | disclosed |