Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HK1 | P19367 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31126425 | 0.85 | MAPT (0.47) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28646815 | 0.85 | MAPT (0.47) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28641174 | 0.85 | ALDH1A1 (0.47) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL31126426 | 0.85 | ALDH1A1 (0.46) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL31126418 | 0.85 | ALDH1A1 (0.46) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28195667 | 0.85 | GCGR (0.47) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28627861 | 0.85 | GCGR (0.47) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28627573 | 0.85 | MAPT (0.44) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28195676 | 0.83 | MAPT (0.45) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL28629705 | 0.82 | MAPK14 (0.47) | MAPTMEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107629022-B | Antibacterial synergist and preparation method and application thereof | 上海医药工业研究院 | 2024-11-12 | — | — | CN | disclosed |
| CN-107625766-B | Application of thiazole compound as antibacterial synergist | 上海医药工业研究院 | 2021-08-31 | — | — | CN | disclosed |
| CN-107629022-A | A kind of Trimethoprim and its preparation method and purposes | 上海医药工业研究院 | 2018-01-26 | — | — | CN | disclosed |
| CN-107625766-A | A kind of thiazole compound is used as the purposes of Trimethoprim | 上海医药工业研究院 | 2018-01-26 | — | — | CN | disclosed |