Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL14238338 | 1.00 | MAPT (0.43) | MAPTHIF1APDE4AKDRCXCR4 | |
| SCHEMBL8505448 | 0.81 | HIF1A (0.46) | MAPTHIF1APDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28852777 | 0.81 | HIF1A (0.46) | MAPTHIF1APDE4AKDRCXCR4 | |
| SCHEMBL8904167 | 0.81 | HIF1A (0.46) | MAPTHIF1APDE4AKDRCXCR4 | |
| Nitric Acid SCHEMBL11794277 | 0.79 | CA5A (0.57) | MAPTHIF1APDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28308117 | 0.79 | HIF1A (0.43) | MAPTHIF1APDE4AKDRCXCR4 | |
| Piperazine SCHEMBL5875381 | 0.79 | CA5A (0.57) | MAPTHIF1APDE4AKDRCXCR4 | |
| Piperazine SCHEMBL14695887 | 0.79 | CA5A (0.57) | MAPTHIF1APDE4AKDRCXCR4 | |
| SCHEMBL29031358 | 0.76 | — | — | |
| SCHEMBL57162 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107501293-A | Two furazano piperazine nitramine class energetic ion salt and its synthetic method | 中国工程物理研究院化工材料研究所 | 2017-12-22 | — | — | CN | claimed |