Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL14695887 | 1.00 | CA5A (0.57) | CA5ACA5BHIF1AMAPTPDE4A | |
| Nitric Acid SCHEMBL11794277 | 1.00 | CA5A (0.57) | CA5ACA5BHIF1AMAPTPDE4A | |
| Nitric Acid SCHEMBL6680089 | 0.96 | — | — | |
| Pyrrolidine SCHEMBL4890817 | 0.87 | — | — | |
| Piperidine SCHEMBL5874511 | 0.84 | ALDH1A1 (0.53) | CA5ACA5BCXCR4SMN1; SMN2 | |
| SCHEMBL8505448 | 0.81 | HIF1A (0.46) | CA5ACA5BHIF1AMAPTPDE4A | |
| SCHEMBL8904167 | 0.81 | HIF1A (0.46) | CA5ACA5BHIF1AMAPTPDE4A | |
| Piperazine SCHEMBL28852777 | 0.81 | HIF1A (0.46) | CA5ACA5BHIF1AMAPTPDE4A | |
| Nitric Acid SCHEMBL5173170 | 0.80 | — | — | |
| Nitric Acid SCHEMBL11606188 | 0.80 | CA5A (0.89) | CA5ACA5BHIF1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478046-B | Method for preparing tertiary amine by taking secondary amine as raw material | 浙江新化化工股份有限公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-119242181-A | Polishing solution with low roughness and high removal amount and preparation method and application thereof | 宁波平恒电子材料有限公司 | 2025-01-03 | — | — | CN | disclosed |
| US-20240228449-A1 | METHOD FOR PREPARING TERTIARY AMINE WITH SECONDARY AMINE AS RAW MATERIAL | ZHEJIANG XINHUA CHEMICAL CO., LTD (CN) | 2024-07-11 | — | — | US | disclosed |
| EP-4324820-A1 | METHOD FOR PREPARING TERTIARY AMINE BY USING SECONDARY AMINE AS RAW MATERIAL | Zhejiang Xinhua Chemical Co., Ltd. (CN) | 2024-02-21 | — | — | EP | disclosed |
| CN-116478046-A | Method for preparing tertiary amine by taking secondary amine as raw material | 浙江新化化工股份有限公司 | 2023-07-25 | — | — | CN | disclosed |
| WO-2023134439-A1 | METHOD FOR PREPARING TERTIARY AMINE BY USING SECONDARY AMINE AS RAW MATERIAL | 浙江新化化工股份有限公司 | 2023-07-20 | — | — | WO | disclosed |
| CN-104341424-B | The method of ionic liquid-catalyzed nitrated synthesis TNAD | 南京理工大学 | 2016-07-06 | — | — | CN | disclosed |
| CN-102614179-B | As be used for the treatment of cognitive impairment, 1-[2-(2, the 4-dimethylphenylsulfanyl)-phenyl] piperazine of the compound to serotonin reabsorption, 5-HT3 and 5-HT1A activity with combination | H. LUNDHECK A/S (DK) | 2015-11-25 | — | — | CN | disclosed |
| CN-102617513-B | As be used for the treatment of cognitive impairment, 1-[2-(2, the 4-dimethylphenylsulfanyl)-phenyl] piperazine of the compound to serotonin reabsorption, 5-HT3 and 5-HT1A activity with combination | H. LUNDHECK A/S (DK) | 2015-09-23 | — | — | CN | disclosed |
| CN-104341424-A | Method for synthesizing TNAD through catalytic nitration by using ionic liquid | UNIV NANJING SCIENCE & TECH | 2015-02-11 | — | — | CN | disclosed |
| CN-103948597-A | Use of 1- [2- (2, 4-dimethylphenylsulfanyl) phenyl ] piperazine for the treatment of pain or residual symptoms of depression associated with sleep and cognition | LUNDBECK & CO AS H | 2014-07-30 | — | — | CN | disclosed |
| CN-102614179-A | 1- [2- (2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment | LUNDBECK & CO AS H | 2012-08-01 | — | — | CN | disclosed |
| CN-102617513-A | 1- [2- (2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 AND 5-HT1A activity for the treatment of cognitive impairment | LUNDBECK & CO AS H | 2012-08-01 | — | — | CN | disclosed |
| CN-101472906-B | 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl ] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment | LUNDBECK & CO AS H | 2012-04-25 | — | — | CN | disclosed |
| CN-101636161-A | 1- [ 2- (2, 4-dimethylphenylsulfanyl) phenyl ] piperazine as a compound with combined 5-hydroxytryptamine reabsorption, 5-HT 3 and 5-HT 1A activity for the treatment of pain or residual symptoms of depression associated with sleep and cognition | LUNDBECK & CO AS H | 2010-01-27 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228449-A1 | METHOD FOR PREPARING TERTIARY AMINE WITH SECONDARY AMINE AS RAW MATERIAL | OTC, AOC1, ODC1 | CA5A 199/4885CA5B 146/4885HIF1A 2242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.