Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8505448 | 0.92 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRMEN1 | |
| Piperazine SCHEMBL28852777 | 0.92 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRMEN1 | |
| SCHEMBL9168744 | 0.83 | CXCR4 (0.56) | HIF1AMAPTPDE4AKDRMEN1 | |
| Piperazine SCHEMBL14238338 | 0.81 | MAPT (0.43) | HIF1AMAPTPDE4AKDRMEN1 | |
| Piperazine SCHEMBL5875381 | 0.81 | CA5A (0.57) | HIF1AMAPTPDE4AKDRMEN1 | |
| Piperazine SCHEMBL28308117 | 0.81 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRMEN1 | |
| Piperazine SCHEMBL28197089 | 0.81 | MAPT (0.43) | HIF1AMAPTPDE4AKDRMEN1 | |
| Nitric Acid SCHEMBL11794277 | 0.81 | CA5A (0.57) | HIF1AMAPTPDE4AKDRMEN1 | |
| Piperazine SCHEMBL14695887 | 0.81 | CA5A (0.57) | HIF1AMAPTPDE4AKDRMEN1 | |
| SCHEMBL28166515 | 0.78 | MEN1 (0.67) | HIF1AMEN1KMT2ACA5ACA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637578-A | AGENTS FOR INFLAMMATION, ISCHEMIC/REPERFUSION INJURY, STROKE, ATHEROSCLEROSIS, AND HYPERTENSION | MONSANTO COMPANY | 1997-06-10 | — | — | US | disclosed |
| US-5610293-A | TREATMENT OF INFLAMMATORY DISEASES, ISCHEMIC/REPERFUSION INJURY, STROKE, ATHERSCLEROSIS, HYPERTENSION | MONSANTO COMPANY (US) | 1997-03-11 | — | — | US | disclosed |