SCHEMBL28197407

SCHEMBL28197407

Cl[Ti](Cl)(Cl)Cl.O=CC(O)(c1ccccc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.40
KDM4E B2RXH2 1/20 0.39
TSHR P16473 3/20 0.37
CYP2C9 P11712 2/20 0.36
ALDH1A1 P00352 4/20 0.34
ESR1 P03372 2/20 0.34
ESR2 Q92731 2/20 0.34
CYP2C19 P33261 2/20 0.34
PTPN1 P18031 1/20 0.34
CYP3A4 P08684 1/20 0.34
KCNN4 O15554 4/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
KEAP1 Q14145 1/20 0.32
NFE2L2 Q16236 1/20 0.32
HIF1A Q16665 1/20 0.32
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL863162 0.91 KDM4E (0.44) CYP1A2KDM4ETSHRCYP2C9ALDH1A1
SCHEMBL811710 0.85 KMT2A (0.45) TSHRALDH1A1NPSR1MAPTKMT2A
SCHEMBL15419956 0.83 ESR2 (0.54) KDM4ETSHRALDH1A1ESR1ESR2
SCHEMBL6629671 0.81 KIF11 (0.41) KDM4ECYP2C9ALDH1A1MAPTKMT2A
SCHEMBL4020288 0.81 KCNN4 (0.53) CYP2C9ALDH1A1CYP2C19CYP3A4KCNN4
SCHEMBL10839093 0.81 MEN1 (0.49) KDM4ETSHRALDH1A1NPSR1MAPT
SCHEMBL8603585 0.79 CYP19A1 (0.50) CYP1A2KDM4ETSHRALDH1A1
SCHEMBL812737 0.76 CES2 (0.47) KDM4EALDH1A1MAPTKMT2A
SCHEMBL4696293 0.76 MEN1 (0.55) CYP1A2KDM4ECYP2C9ALDH1A1CYP2C19
SCHEMBL5775887 0.75 MEN1 (0.52) CYP1A2TSHRCYP3A4NPSR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107513261-A A kind of Noryl aeroge and preparation method thereof 芜湖凌梦电子商务有限公司 2017-12-26 CN disclosed