Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL863162 | 0.89 | KDM4E (0.44) | ALDH1A1TDP1MAPK1KDM4EKMT2A | |
| SCHEMBL6631834 | 0.82 | SMN1; SMN2 (0.42) | ALDH1A1TDP1MAPK1MEN1KMT2A | |
| SCHEMBL11619282 | 0.82 | KDM4E (0.41) | KIF11ALDH1A1TDP1MAPK1MAOA | |
| SCHEMBL28197407 | 0.81 | CYP1A2 (0.40) | ALDH1A1TDP1MAPK1KDM4EKMT2A | |
| SCHEMBL15419956 | 0.81 | ESR2 (0.54) | KIF11ALDH1A1TDP1KDM4ELMNA | |
| SCHEMBL10839093 | 0.79 | MEN1 (0.49) | KIF11ALDH1A1MAPK1KDM4EMEN1 | |
| SCHEMBL811710 | 0.79 | KMT2A (0.45) | KIF11ALDH1A1MAPK1PDPK1MEN1 | |
| SCHEMBL4020288 | 0.79 | KCNN4 (0.53) | KIF11ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL5528030 | 0.78 | ALDH1A1 (0.43) | KIF11ALDH1A1TDP1MAPK1MAOA | |
| SCHEMBL10538145 | 0.78 | ALDH1A1 (0.43) | KIF11ALDH1A1TDP1MAPK1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425283-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003018589-A1 | NOVEL 4-AMINOFUROPYRIMIDINES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2003-03-06 | — | — | WO | disclosed |