Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28197945 | 0.80 | DAO (0.42) | GAACSNK1DCSNK1ECLK1DYRK1A | |
| SCHEMBL255425 | 0.77 | CLK1 (0.48) | CSNK1DCSNK1ECLK1DYRK1AIMPDH2 | |
| SCHEMBL5262554 | 0.76 | NCOA3 (0.45) | GAACLK1DYRK1AALDH1A1SMN1; SMN2 | |
| SCHEMBL28855734 | 0.76 | GAA (0.33) | GAACSNK1DCSNK1ECLK1DYRK1A | |
| SCHEMBL27784056 | 0.74 | KEAP1 (0.46) | ALDH1A1SMN1; SMN2KDM4EHPGDTDP1 | |
| SCHEMBL28156867 | 0.74 | TNF (0.44) | NPC1ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL5096070 | 0.74 | ALDH1A1 (0.40) | CLK1DYRK1AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1018440 | 0.73 | CLK1 (0.46) | GAACSNK1DCSNK1ECLK1DYRK1A | |
| SCHEMBL2300291 | 0.73 | TDP1 (0.52) | GAAIMPDH2NPC1ALDH1A1RAB9A | |
| SCHEMBL29757578 | 0.73 | TDP1 (0.52) | GAAIMPDH2NPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007113565-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |