SCHEMBL28198345

SCHEMBL28198345

COC(=O)[CH]c1ccc(N)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.44
CA2 P00918 3/20 0.44
CA12 O43570 1/20 0.44
TYR P14679 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
CYP19A1 P11511 5/20 0.42
EPHX2 P34913 1/20 0.41
APP P05067 2/20 0.41
TTR P02766 1/20 0.41
NQO2 P16083 2/20 0.40
KDM1A O60341 1/20 0.40
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
RAB9A P51151 1/20 0.39
PTPN1 P18031 1/20 0.39
ALDH1A1 P00352 1/20 0.38
MAPK1 P28482 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5749467 0.81 CA1 (0.66) CA1CA2CA12TYRCA7
SCHEMBL11371533 0.81 TDP1 (0.48) CA1CA2CA12TYRCA7
SCHEMBL1233254 0.80 CA1 (0.70) CA1CA2CA12TYRCA7
SCHEMBL1233253 0.80 CA1 (0.70) CA1CA2CA12TYRCA7
SCHEMBL11375166 0.79 GSK3B (0.56) CA1CA2MAPTRAB9AALDH1A1
SCHEMBL5454115 0.79 PTGS2 (0.47) CA1CA2CA12TYRCA7
Hydrochloric Acid SCHEMBL7439394 0.79 CA1 (0.68) CA1CA2CA12TYRCA7
Hydrochloric Acid SCHEMBL3552479 0.79 CA1 (0.68) CA1CA2CA12TYRCA7
SCHEMBL294835 0.78 TSHR (0.46) CA1CA2CA12TYRCA7
SCHEMBL11373820 0.77 NPSR1 (0.50) CYP19A1KDM1AGAAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107614514-A Modified using the antibody specificity of IgG binding peptides 国立大学法人鹿儿岛大学 2018-01-19 CN disclosed