Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678865 | 0.86 | TDP1 (0.66) | L3MBTL1TDP1POLBGPR35TSHR | |
| SCHEMBL4691688 | 0.81 | GPR35 (0.53) | L3MBTL1TDP1POLBMAPK1VCAM1 | |
| SCHEMBL5307875 | 0.80 | TSHR (0.58) | L3MBTL1TDP1POLBMAPK1VCAM1 | |
| SCHEMBL27511511 | 0.80 | VCAM1 (0.60) | L3MBTL1TDP1POLBMAPK1VCAM1 | |
| SCHEMBL11854765 | 0.80 | MAPK1 (0.60) | L3MBTL1TDP1POLBMAPK1VCAM1 | |
| SCHEMBL4693020 | 0.80 | TDP1 (0.50) | L3MBTL1TDP1POLBMAPK1VCAM1 | |
| SCHEMBL4687664 | 0.80 | TDP1 (0.73) | L3MBTL1TDP1POLBMAPK1VCAM1 | |
| SCHEMBL4688384 | 0.80 | TDP1 (0.50) | L3MBTL1TDP1POLBMAPK1VCAM1 | |
| Benzophenone SCHEMBL27290369 | 0.80 | MAPK1 (0.64) | L3MBTL1TDP1POLBMAPK1VCAM1 | |
| SCHEMBL19972047 | 0.79 | TDP1 (0.49) | L3MBTL1TDP1ALDH1A1GPR35TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105324379-B | Benzimidazole derivatives as bromodomain inhibitors | 吉利德科学公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-105102453-B | benzimidazolone derivatives as bromodomain inhibitors | 吉利德科学公司 | 2018-04-06 | — | — | CN | disclosed |