Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TTR | P02766 | 3/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27660224 | 0.95 | TDP1 (0.50) | TDP1L3MBTL1MAPK1VCAM1ALDH1A1 | |
| SCHEMBL28248082 | 0.90 | MAPK1 (0.45) | TDP1L3MBTL1MAPK1VCAM1ALDH1A1 | |
| Benzoic Acid Hydrazide SCHEMBL28020272 | 0.89 | CTSD (0.51) | TDP1L3MBTL1MAPK1VCAM1ALDH1A1 | |
| SCHEMBL17819747 | 0.84 | TDP1 (0.64) | TDP1L3MBTL1MEN1KMT2AGPR35 | |
| SCHEMBL355378 | 0.84 | TDP1 (0.64) | TDP1L3MBTL1MEN1KMT2AGPR35 | |
| SCHEMBL1349352 | 0.82 | MAPK1 (0.51) | TDP1MAPK1VCAM1ALDH1A1MEN1 | |
| SCHEMBL28085778 | 0.82 | MAPK1 (0.51) | TDP1L3MBTL1MAPK1VCAM1ALDH1A1 | |
| SCHEMBL4691688 | 0.81 | GPR35 (0.53) | TDP1L3MBTL1MAPK1VCAM1ALDH1A1 | |
| SCHEMBL28085787 | 0.81 | MAPK1 (0.50) | TDP1MAPK1VCAM1ALDH1A1MEN1 | |
| SCHEMBL11854765 | 0.80 | MAPK1 (0.60) | TDP1L3MBTL1MAPK1VCAM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107033145-B | Benzothiazine and benzothiadiazines compound and preparation and application | 浙江大学 | 2019-11-22 | — | — | CN | disclosed |
| CN-109503686-A | New nucleoside phosphoramidate compound and its application | 南京圣和药业股份有限公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-109476672-A | NOVEL HETEROCYCLIC DERIVATIVE COMPOUND AND USE THEREOF | 韩美药品株式会社 | 2019-03-15 | — | — | CN | disclosed |
| CN-108863820-A | A kind of synthetic method of substituted o-phenylenediamine | 枣庄学院 | 2018-11-23 | — | — | CN | disclosed |
| CN-108602770-A | Novel biphenol compound or its salt | 大鹏药品工业株式会社 | 2018-09-28 | — | — | CN | disclosed |
| CN-105814054-B | Condensed imidazole and pyrazole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-108546277-A | New nucleoside phosphoramidate compound and its application | 南京圣和药业股份有限公司 | 2018-09-18 | — | — | CN | disclosed |
| CN-108503593-A | 2- amino-metadiazine compounds and its application | 暨南大学 | 2018-09-07 | — | — | CN | disclosed |
| CN-108314697-A | New nucleoside phosphoramidate compound and its application | 南京圣和药业股份有限公司 | 2018-07-24 | — | — | CN | disclosed |
| CN-108290878-A | NOVEL FERROPORTIN INHIBITORS | 威佛（国际）股份公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-101018552-A | Intracellular receptor modulator compounds and methods | LIGAND PHARM INC (US) | 2007-08-15 | — | — | CN | disclosed |
| US-7141584-B2 | guanidine derivatives containing phenyl and imidazole rings; useful for treating pain conditions from a wide variety of causes such as cancer, trauma, surgery, inflammation etc. | ROCHE PALO ALTO LLC (US) | 2006-11-28 | — | — | US | disclosed |
| US-20040122053-A1 | 2-(substituted-phenyl)amino-imidazoline derivatives | BLEY KEITH ROGER (US) | 2004-06-24 | — | — | US | disclosed |
| US-6693200-B2 | IP RECEPTOR ANTAGONISTS; ANTIINFLAMMATORIES AND ANALGESICS | SYNTEX (U.S.A.) LLC | 2004-02-17 | — | — | US | disclosed |
| US-20030229123-A1 | Antiinflammatory agents; antiallergens; lipoxygenase or phospholipase inhibitors | BLEY KEITH ROGER (US) | 2003-12-11 | — | — | US | disclosed |
| US-6596876-B2 | Prostaglandin I2 inhibitors | SYNTEX (U.S.A.) LLC | 2003-07-22 | — | — | US | disclosed |
| US-20030036655-A1 | 2-(substituted-phenyl)amino-imidazoline derivatives | BLEY KEITH ROGER (US) | 2003-02-20 | — | — | US | disclosed |
| US-6472536-B1 | SUCH AS 2-(4-(4-CYCLOPENTYLOXYBENZYL)PHENYL)AMINO-IMIDAZOLINE; ANTINOCICEPTIVE AGENTS; IP RECEPTOR ANTAGONISTS; TREATING INFLAMMATORY PAIN | SYNTEX (U.S.A.) LLC | 2002-10-29 | — | — | US | disclosed |
| US-6184242-B1 | 2-(substituted-phenyl)amino-imidazoline derivatives | SYNTEX USA (LLC) | 2001-02-06 | — | — | US | disclosed |
| EP-0902018-A2 | 2-(Arylphenyl)amino-imidazoline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229123-A1 | Antiinflammatory agents; antiallergens; lipoxygenase or phospholipase inhibitors | LTB4R2, LTB4R, ALOX5 | TDP1 2963/4885L3MBTL1 4289/4885MAPK1 1105/4885 |
| US-20040122053-A1 | 2-(substituted-phenyl)amino-imidazoline derivatives | GIPR, GRK2, TBXA2R | TDP1 3471/4885L3MBTL1 4796/4885MAPK1 1553/4885 |
| US-20030036655-A1 | 2-(substituted-phenyl)amino-imidazoline derivatives | GIPR, TBXA2R, GRK2 | TDP1 3302/4885L3MBTL1 4756/4885MAPK1 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.