Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | UBE2M | P61081 | 4/20 | 0.45 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821443 | 0.91 | DRD2 (0.53) | DRD2DRD3SIGMAR1ACHEBCHE | |
| SCHEMBL2819916 | 0.88 | DRD2 (0.54) | DRD2DRD3SIGMAR1ACHEKDM4E | |
| SCHEMBL2818891 | 0.87 | DRD2 (0.52) | DRD2DRD3SIGMAR1ACHEBCHE | |
| SCHEMBL2822558 | 0.87 | ACHE (0.51) | DRD2DRD3SIGMAR1ACHEALDH1A1 | |
| SCHEMBL1022646 | 0.85 | DRD2 (0.72) | DRD2DRD3SIGMAR1ACHEKDM4E | |
| SCHEMBL27759404 | 0.85 | UBE2M (0.52) | SIGMAR1DRD4UBE2MDCUN1D1 | |
| SCHEMBL2821161 | 0.85 | ACHE (0.54) | DRD2DRD3SIGMAR1ACHEKDM4E | |
| SCHEMBL2822514 | 0.84 | ACHE (0.67) | ACHEKDM4EGAABCHEBACE1 | |
| SCHEMBL2819979 | 0.83 | DRD2 (0.52) | DRD2DRD3ACHEBCHEBACE1 | |
| SCHEMBL2820578 | 0.83 | DRD2 (0.63) | DRD2DRD3ACHEKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466153-B2 | Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-06-18 | — | — | US | claimed |
| EP-2091938-B1 | PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-27 | — | — | EP | claimed |
| US-20100076187-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN-CILAG S.A. (ES) | 2010-03-25 | — | — | US | claimed |
| US-8466153-B2 | Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-06-18 | — | — | US | disclosed |
| US-8466153-B2 | Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-06-18 | — | — | US | disclosed |
| US-8466153-B2 | Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-06-18 | — | — | US | disclosed |
| EP-2091938-B1 | PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-27 | — | — | EP | disclosed |
| EP-2091938-B1 | PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-27 | — | — | EP | disclosed |
| US-20100076187-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN-CILAG S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
| US-20100076187-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN-CILAG S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
| US-20100076187-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN-CILAG S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
| WO-2008068277-A1 | PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076187-A1 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | DRD2, GRIN2C, GRIN2A | DRD2 1/4885DRD3 8/4885SIGMAR1 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.