Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GLS | O94925 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28001770 | 0.87 | LOXL2 (0.58) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL3136413 | 0.80 | KDM4E (0.56) | MEN1KMT2AKDM4EMAPTGLS | |
| SCHEMBL3720399 | 0.80 | KDM4E (0.59) | MEN1KMT2AKDM4EMAPTGLS | |
| SCHEMBL21860417 | 0.80 | MEN1 (0.43) | MEN1KMT2AKDM4EMAPTGLS | |
| SCHEMBL6114797 | 0.79 | CYP19A1 (0.54) | MEN1KMT2AKDM4EMAPTGLS | |
| SCHEMBL3783847 | 0.79 | GLS (0.49) | MEN1KMT2AKDM4EMAPTGLS | |
| Hydrochloric Acid SCHEMBL3712126 | 0.79 | KDM4E (0.57) | MEN1KMT2AKDM4EMAPTGLS | |
| SCHEMBL763204 | 0.79 | MAPT (0.54) | MEN1KMT2AKDM4EMAPTMAPK8 | |
| SCHEMBL27612792 | 0.76 | KDM4E (0.42) | MEN1KMT2AKDM4EMAPTGLS | |
| SCHEMBL5495469 | 0.76 | CYP19A1 (0.54) | MEN1KMT2AKDM4EMAPTGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110278711-A | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | 百时美施贵宝公司 | 2019-09-24 | — | — | CN | disclosed |
| CN-107709295-A | Tricyclic sulfones as ROR gamma modulators | 百时美施贵宝公司 | 2018-02-16 | — | — | CN | disclosed |