SCHEMBL28200399

SCHEMBL28200399

C=CC(=O)N(c1ccccc1)c1ccc(N)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
TDP1 Q9NUW8 2/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
KDM4E B2RXH2 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
MAPT P10636 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
TRPM8 Q7Z2W7 5/20 0.47
NPSR1 Q6W5P4 2/20 0.45
NPC1 O15118 2/20 0.39
POLB P06746 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39
AKT1 P31749 1/20 0.38
ATM Q13315 1/20 0.38
CYP1B1 Q16678 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1629579 0.89 TRPM8 (0.57) ALDH1A1TDP1L3MBTL1MAPTTRPM8
SCHEMBL28449476 0.82 TRPM8 (0.47) ALDH1A1TDP1L3MBTL1TRPM8NPSR1
SCHEMBL22196912 0.82 TRPM8 (0.47) ALDH1A1TDP1L3MBTL1MAPTTRPM8
SCHEMBL25797681 0.82 TRPM8 (0.47) ALDH1A1TDP1L3MBTL1MAPTTRPM8
SCHEMBL18763031 0.82 TRPM8 (0.47) ALDH1A1TDP1L3MBTL1KDM4EMAPT
SCHEMBL27588424 0.81 MAPT (0.32) ALDH1A1TDP1CYP3A4MAPTTRPM8
Styrene SCHEMBL2231382 0.80 TRPM8 (0.58) ALDH1A1TDP1L3MBTL1TRPM8NPSR1
SCHEMBL4903337 0.78 ALDH1A1 (0.48) ALDH1A1TDP1L3MBTL1KDM4ECYP3A4
SCHEMBL7864460 0.77 NPSR1 (0.46) ALDH1A1TDP1L3MBTL1CYP3A4CYP2C9
SCHEMBL11823197 0.77 ALDH1A1 (0.56) ALDH1A1TDP1L3MBTL1KDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105683257-B Addition-fragmentation oligomers containing allyl disulfide 3M创新有限公司 2018-02-13 CN disclosed