Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.88 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ABAT | P80404 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | F11 | P03951 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76433 | 0.94 | — | — | |
| SCHEMBL2545537 | 0.94 | LOXL2 (1.00) | LOXL2GFERHRH3ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL3171444 | 0.91 | LOXL2 (0.94) | LOXL2GFERHRH3ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL10796330 | 0.91 | LOXL2 (0.94) | LOXL2GFERHRH3ALDH1A1CYP3A4 | |
| SCHEMBL3787138 | 0.86 | LOXL2 (0.83) | LOXL2GFERHRH3ALDH1A1CYP3A4 | |
| Ethylenediamine SCHEMBL8661671 | 0.84 | MEN1 (0.67) | LOXL2GFERALDH1A1CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL31716096 | 0.83 | LOXL2 (0.79) | LOXL2GFERHRH3ALDH1A1CYP3A4 | |
| SCHEMBL27238704 | 0.80 | HRH3 (0.79) | LOXL2HRH3ABATMAPTTAAR1 | |
| SCHEMBL15828 | 0.80 | HRH3 (0.79) | LOXL2HRH3ABATMAPTTAAR1 | |
| Benzylamine SCHEMBL23044693 | 0.80 | LOXL2 (0.78) | LOXL2CYP3A4TSHRTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104619403-B | Composite semipermeable membrane | 东丽株式会社 | 2018-01-30 | — | — | CN | disclosed |