SCHEMBL28201014

SCHEMBL28201014

O=[N+]([O-])c1ccc(Cc2ccc[nH]2)c([N+](=O)[O-])c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.50
ALOX5 P09917 1/20 0.44
TDP1 Q9NUW8 2/20 0.44
ALDH1A1 P00352 5/20 0.42
GPR35 Q9HC97 2/20 0.42
MAPK1 P28482 2/20 0.42
HIF1A Q16665 2/20 0.42
TSHR P16473 2/20 0.42
TP53 P04637 1/20 0.42
HPGD P15428 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MAPT P10636 3/20 0.42
KDM4E B2RXH2 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
TXNRD1 Q16881 1/20 0.41
TXNRD3 Q86VQ6 1/20 0.41
TXNRD2 Q9NNW7 1/20 0.41
RAB9A P51151 1/20 0.39
HSP90AA1 P07900 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7471503 0.81 ALDH1A1 (0.51) ALDH1A1TSHRHPGDSMN1; SMN2MEN1
SCHEMBL5333075 0.81 CYP1A2 (0.66) CYP1A2ALOX5TDP1ALDH1A1GPR35
SCHEMBL11429326 0.76 CYP1A2 (0.57) CYP1A2ALOX5TDP1ALDH1A1GPR35
SCHEMBL7471515 0.76 POLB (0.50) CYP1A2ALDH1A1TSHRHPGDSMN1; SMN2
SCHEMBL10536120 0.76 TSHR (0.54) CYP1A2TDP1ALDH1A1TSHRMAPT
SCHEMBL5248985 0.75 CYP1A2 (0.59) CYP1A2ALOX5TDP1ALDH1A1GPR35
SCHEMBL27961047 0.75 CYP1A2 (0.68) CYP1A2ALOX5TDP1ALDH1A1GPR35
SCHEMBL11775774 0.74 CYP1A2 (0.58) CYP1A2ALOX5TDP1ALDH1A1GPR35
SCHEMBL11778027 0.74 CYP1A2 (0.58) CYP1A2TDP1ALDH1A1GPR35MAPK1
SCHEMBL9173837 0.73 CYP1A2 (0.60) CYP1A2ALOX5TDP1ALDH1A1GPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105669548-B A kind of method of manganese compound catalysis oxidation pyridine compounds and their synthesis ketone 中国科学院大连化学物理研究所 2018-04-03 CN disclosed
CN-107652664-A A kind of photosensitive colour-changing TPU film for adhering film to glass and preparation method thereof 东莞市雄林新材料科技股份有限公司 2018-02-02 CN disclosed