SCHEMBL7471503

SCHEMBL7471503

O=[N+]([O-])c1ccccc1Cc1ccc[nH]1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.51
TSHR P16473 1/20 0.51
HPGD P15428 1/20 0.47
AR P10275 1/20 0.47
HTT P42858 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
ACHE P22303 1/20 0.39
HSD17B10 Q99714 1/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
RECQL P46063 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
ALDH3A1 P30838 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28400893 0.87 ALDH1A1 (0.51) ALDH1A1TSHRHPGDARHTT
SCHEMBL28201014 0.81 CYP1A2 (0.50) ALDH1A1TSHRHPGDRAB9ASMN1; SMN2
SCHEMBL301933 0.80 ALDH1A1 (0.69) ALDH1A1TSHRHPGDARHTT
Ammonia Solution, Strong SCHEMBL10338964 0.78 ALDH1A1 (0.67) ALDH1A1TSHRHPGDARHTT
SCHEMBL5425469 0.76 AR (0.50) ALDH1A1TSHRHPGDARHTT
SCHEMBL28001560 0.75 ALDH1A1 (0.50) ALDH1A1TSHRHPGDARHTT
SCHEMBL7626565 0.74 ALDH1A1 (0.49) ALDH1A1TSHRHPGDARHTT
SCHEMBL4690719 0.74 ALDH1A1 (0.56) ALDH1A1TSHRHPGDARHTT
SCHEMBL3202573 0.73 ALDH1A1 (0.72) ALDH1A1TSHRHPGDHTTL3MBTL1
SCHEMBL10956103 0.73 ADRA2A (0.52) ALDH1A1TSHRHPGDARL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906279-B1 PYRROLE DERIVATIVES HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-6136844-A ANTIINFLAMMATORY AGENT; AUTOIMMUNE DISEASE SYNTEX (U.S.A.) INC. (US) 2000-10-24 US disclosed
US-6127402-A AN INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE AND ARE ANTI-INFLAMMATORY AND ANALGESIC AGENTS SYNTEX (U.S.A.) INC. (US) 2000-10-03 US disclosed
US-5952368-A AN INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE, ANTIINFLAMMATORY AND ANALGESIC AGENTS SYNTEX (U.S.A.) INC. (US) 1999-09-14 US disclosed
EP-0906279-A1 NOVEL PYRROLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-04-07 EP disclosed
WO-1997046524-A1 NOVEL PYRROLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1997-12-11 WO disclosed
EP-0001585-A1 Piperazino-pyrrolobenzodiazepines, methods for their preparation and pharmaceutical compositions containing them CIBA-GEIGY AG (CH) 1979-05-02 EP disclosed