SCHEMBL28201206

SCHEMBL28201206

NC(F)(C(F)F)C(O)(F)C(=O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 6/20 0.52
SRC P12931 1/20 0.40
MLYCD O95822 1/20 0.39
TSHR P16473 2/20 0.38
MAPT P10636 2/20 0.38
HSD17B10 Q99714 2/20 0.38
POLB P06746 1/20 0.38
CYP3A4 P08684 1/20 0.38
PARP1 P09874 1/20 0.38
CYP2C19 P33261 1/20 0.38
RECQL P46063 1/20 0.38
BLM P54132 1/20 0.38
PMP22 Q01453 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CES2 O00748 2/20 0.35
ALDH1A1 P00352 2/20 0.35
DAO P14920 1/20 0.35
NAPRT Q6XQN6 1/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3345524 0.74 CES1 (0.50) CES1SRCMLYCDTSHRMAPT
SCHEMBL11475855 0.73 CES1 (0.59) CES1SRCMLYCDTSHRMAPT
SCHEMBL3345516 0.73 CES1 (0.53) CES1SRCMLYCDTSHRMAPT
SCHEMBL14645923 0.72 CES1 (0.56) CES1SRCTSHRMAPTHSD17B10
SCHEMBL11474520 0.70 CES1 (0.55) CES1SRCMLYCDTSHRHSD17B10
SCHEMBL3134419 0.70 CES1 (0.60) CES1SRCMLYCDTSHRMAPT
SCHEMBL669434 0.69 CES1 (0.58) CES1SRCTSHRMAPTHSD17B10
SCHEMBL33083 0.69 CES1 (1.00) CES1MLYCDTSHRCES2ALDH1A1
SCHEMBL7907262 0.69 CES1 (0.73) CES1SRCMLYCDTSHRMAPT
Benzene SCHEMBL27672585 0.69 CES1 (1.00) CES1MLYCDTSHRCES2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107677735-A A kind of HPLC analysis methods of (S) 2 aminopropanol 上海朴颐化学科技有限公司 2018-02-09 CN disclosed