Tetrahydrofuran

Tetrahydrofuran

SCHEMBL28201360

C1CCOC1.CC(C)C(NC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CTSK P43235 4/20 0.50
CTSS P25774 2/20 0.50
CTSL P07711 2/20 0.46
CTSB P07858 1/20 0.46
PREP P48147 1/20 0.44
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA7 P43166 1/20 0.43
TSHR P16473 2/20 0.42
TRPA1 O75762 2/20 0.40
KMT2A Q03164 1/20 0.40
SDCBP O00560 1/20 0.40
SDC2 P34741 1/20 0.40
CYP2D6 P10635 1/20 0.39
ALDH1A1 P00352 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ALOX15 P16050 1/20 0.39
APP P05067 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofuran SCHEMBL28201359 1.00 CTSK (0.50) CTSKCTSSCTSLCTSBPREP
Fluoride SCHEMBL7360449 0.89 CTSK (0.59) CTSKCTSSCTSLCTSBPREP
Fluoride SCHEMBL7360444 0.89 CTSK (0.59) CTSKCTSSCTSLCTSBPREP
SCHEMBL467994 0.87 CTSK (0.61) CTSKCTSSCTSLCTSBPREP
SCHEMBL59323 0.87 CTSK (0.61) CTSKCTSSCTSLCTSBPREP
SCHEMBL256794 0.87 CTSK (0.61) CTSKCTSSCTSLCTSBPREP
SCHEMBL29674710 0.87 CTSK (0.61) CTSKCTSSCTSLCTSBPREP
Ammonia Solution, Strong SCHEMBL28313812 0.85 CTSK (0.59) CTSKCTSSCTSLCTSBPREP
SCHEMBL28058549 0.85 CTSK (0.59) CTSKCTSSCTSLCTSBPREP
Succinic Acid SCHEMBL29698979 0.83 CTSK (0.57) CTSKCTSSCTSLCTSBPREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107635989-A Benzimidizole derivatives as bromine domain inhibitor 葛兰素史克知识产权开发有限公司 2018-01-26 CN disclosed