Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piritrexim. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 5/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piritrexim SCHEMBL9687400 | 0.91 | DHFR (0.98) | DHFR | |
| Piritrexim SCHEMBL29462191 | 0.89 | DHFR (1.00) | DHFR | |
| Piritrexim SCHEMBL8124 | 0.89 | DHFR (1.00) | DHFR | |
| Piritrexim SCHEMBL29365922 | 0.89 | DHFR (1.00) | DHFR | |
| Piritrexim SCHEMBL135624 | 0.79 | DHFR (0.79) | DHFR | |
| SCHEMBL10644572 | 0.78 | DHFR (0.78) | DHFR | |
| SCHEMBL10644399 | 0.78 | DHFR (0.78) | DHFR | |
| Trimetrexate SCHEMBL6013903 | 0.75 | DHFR (0.70) | DHFR | |
| SCHEMBL11006578 | 0.74 | DHFR (0.71) | DHFR | |
| SCHEMBL10465187 | 0.72 | DHFR (0.67) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107735097-A | Extracellular matrix composition for treating cancer or immunity disease | 希斯托金公司 | 2018-02-23 | — | — | CN | disclosed |