Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piritrexim. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 5/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piritrexim SCHEMBL29365922 | 1.00 | DHFR (1.00) | DHFR | |
| Piritrexim SCHEMBL8124 | 1.00 | DHFR (1.00) | DHFR | |
| Piritrexim SCHEMBL9687400 | 0.99 | DHFR (0.98) | DHFR | |
| Piritrexim SCHEMBL28201443 | 0.89 | DHFR (0.80) | DHFR | |
| Piritrexim SCHEMBL135624 | 0.89 | DHFR (0.79) | DHFR | |
| SCHEMBL10644399 | 0.88 | DHFR (0.78) | DHFR | |
| SCHEMBL10644572 | 0.88 | DHFR (0.78) | DHFR | |
| Trimetrexate SCHEMBL6013903 | 0.84 | DHFR (0.70) | DHFR | |
| SCHEMBL11006578 | 0.83 | DHFR (0.71) | DHFR | |
| SCHEMBL10465187 | 0.80 | DHFR (0.67) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3681504-B1 | METHODS OF DETECTION USING X-RAY FLUORESCENCE | ICAGEN INC (US) | 2023-08-23 | — | — | EP | disclosed |
| US-11266615-B2 | Pyrimethamine-based pharmaceutical compositions and methods for fabricating thereof | FIFTH THIRD BANK, NATIONAL ASSOCIATION, AS AGENT | 2022-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11266615-B2 | Pyrimethamine-based pharmaceutical compositions and methods for fabricating thereof | TYMP, DPYD, TYMS | DHFR 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.