Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21503642 | 0.81 | CYP2E1 (0.44) | CYP1A2CYP2C19CYP2C9LOXL2ALDH1A1 | |
| SCHEMBL17981893 | 0.77 | LOXL2 (0.48) | CYP2C19CYP2C9LOXL2 | |
| SCHEMBL18986509 | 0.77 | LOXL2 (0.57) | CYP1A2CYP2C19CYP2C9LOXL2 | |
| SCHEMBL805511 | 0.77 | ALDH1A1 (0.45) | CYP1A2CYP2C19CYP2C9LOXL2ALDH1A1 | |
| SCHEMBL19997562 | 0.75 | TDP1 (0.44) | MAPTCYP3A4ALOX15TSHRTDP1 | |
| SCHEMBL14969341 | 0.75 | IDO1 (0.52) | CYP1A2CYP2C19GLACYP2C9CLK4 | |
| SCHEMBL17318488 | 0.74 | SCN9A (0.40) | MAPTLOXL2ALDH1A1LATS1CYP11B1 | |
| SCHEMBL22493240 | 0.74 | LATS1 (0.39) | LOXL2ALDH1A1LATS1SSTR4SLC22A12 | |
| SCHEMBL20519350 | 0.74 | PARP1 (0.35) | CYP2C19CYP2C9LOXL2CYP11B1CYP11B2 | |
| SCHEMBL27290295 | 0.74 | CYP11B1 (0.34) | MAPTCYP2C19CYP2C9LOXL2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683188-B | The ring pyridinyl derivatives of condensed ring two as FGFR4 inhibitor | 诺华股份有限公司 | 2018-02-09 | — | — | CN | disclosed |