Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.55 |
| ▸ | RXRB | P28702 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TPMT | P51580 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392534 | 0.85 | KDM4E (0.58) | RXRARXRBKDM4EKMT2ATPMT | |
| SCHEMBL27786187 | 0.80 | PTPN1 (0.58) | MCL1AKR1C2AKR1C1ALDH1A1DHODH | |
| SCHEMBL28201890 | 0.79 | TDP1 (0.53) | RXRARXRBKDM4EKMT2AMEN1 | |
| SCHEMBL29898488 | 0.77 | RXRA (0.50) | RXRARXRBKDM4EKMT2ATPMT | |
| SCHEMBL2806484 | 0.76 | KDM4E (0.79) | KDM4EKMT2ATPMTMEN1TDP1 | |
| SCHEMBL28026029 | 0.75 | AKR1C2 (0.56) | RXRARXRBKDM4EMCL1FTO | |
| SCHEMBL12446321 | 0.74 | TPMT (0.73) | RXRARXRBTPMTCNR2ALDH1A1 | |
| SCHEMBL2808086 | 0.74 | KDM4E (0.76) | KDM4EKMT2ATPMTMEN1TDP1 | |
| SCHEMBL1259082 | 0.74 | KDM4E (0.63) | KDM4EKMT2ATPMTMEN1TDP1 | |
| SCHEMBL2280055 | 0.74 | FTO (0.43) | RXRARXRBKDM4ETPMTMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164113-B | Pyrroloamide inhibitors | 艾伯维公司 | 2018-03-02 | — | — | CN | claimed |
| CN-105164113-B | Pyrroloamide inhibitors | 艾伯维公司 | 2018-03-02 | — | — | CN | disclosed |