Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | PPOX | P50336 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 2/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475271 | 0.77 | AHR (0.50) | MAP4K4NOTUMPDE3BPDE3APPOX | |
| SCHEMBL16115826 | 0.76 | F11 (0.39) | MAP4K4PDE3BPDE3APPOXS100A4 | |
| SCHEMBL31252350 | 0.73 | F11 (0.42) | HDAC6AOC3F11 | |
| SCHEMBL3476831 | 0.71 | NOTUM (0.64) | MAP4K4NOTUMAOC3ALDH2KCNH2 | |
| SCHEMBL3477513 | 0.71 | MAP4K4 (0.45) | MAP4K4NOTUMPDE3BPDE3ASCN8A | |
| SCHEMBL16115727 | 0.71 | F11 (0.44) | S100A4F11 | |
| SCHEMBL17629754 | 0.71 | NR3C1 (0.38) | S100A4F11ALDH1A1SCN8ASCN10A | |
| SCHEMBL16144671 | 0.69 | F11 (0.45) | MAP4K4F11 | |
| SCHEMBL19620153 | 0.69 | MAP4K4 (0.43) | MAP4K4NOTUMPDE3BPDE3APPOX | |
| SCHEMBL608199 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164513-A | Substituted oxo pyridine derivative and its purposes in terms of cardiovascular disorder is treated | 拜耳制药股份公司 | 2018-06-15 | — | — | CN | disclosed |
| CN-105164122-B | Substituted oxopyridine derivatives and their use in the treatment of cardiovascular disorders | 拜耳制药股份公司 | 2018-02-02 | — | — | CN | disclosed |