Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.49 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1075113 | 0.85 | ALDH1A1 (0.53) | NAMPTHDAC6HDAC8ALDH1A1KDM4E | |
| SCHEMBL14590639 | 0.84 | HSD17B3 (0.57) | NAMPTHSD17B3HDAC6HDAC8KDM1A | |
| SCHEMBL26075696 | 0.80 | HSD17B3 (0.52) | NAMPTHSD17B3HDAC6HDAC8KDM1A | |
| SCHEMBL28956614 | 0.79 | HDAC6 (0.50) | NAMPTHDAC6HDAC8 | |
| SCHEMBL29168673 | 0.78 | HDAC6 (0.56) | NAMPTHDAC6HDAC8DPP9ALDH1A1 | |
| SCHEMBL1027717 | 0.78 | NAMPT (0.54) | NAMPTHDAC6HDAC8ALDH1A1KDM4E | |
| SCHEMBL1393814 | 0.78 | NR1H2 (0.50) | NAMPTHSD17B3HDAC6HDAC8DPP9 | |
| SCHEMBL14625863 | 0.77 | HSD17B3 (0.50) | NAMPTHSD17B3HDAC6HDAC8KDM1A | |
| SCHEMBL566491 | 0.77 | HDAC6 (0.51) | NAMPTHDAC6HDAC8 | |
| SCHEMBL4232286 | 0.77 | NR1H2 (0.56) | NAMPTHSD17B3HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849047-A | Biphenyl derivative, preparation method and medical application thereof | 四川海思科制药有限公司 | 2018-03-27 | — | — | CN | disclosed |