Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28208523 | 0.77 | ALDH1A1 (0.34) | ALDH1A1KDM4EMAPTL3MBTL1HSD17B10 | |
| SCHEMBL12074841 | 0.76 | HIF1A (0.47) | ALDH1A1SMN1; SMN2KDM4EHIF1ALMNA | |
| SCHEMBL1506928 | 0.74 | TRIM24 (0.53) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6442608 | 0.73 | CES2 (0.43) | ALDH1A1 | |
| SCHEMBL20551270 | 0.73 | CES2 (0.43) | ALDH1A1 | |
| SCHEMBL6987741 | 0.72 | ALDH1A1 (0.55) | TRIM24TRIM33ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL17604466 | 0.72 | DGAT1 (0.35) | ALDH1A1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL6443959 | 0.72 | TDP1 (0.35) | HSD17B10TDP1 | |
| SCHEMBL26664767 | 0.72 | TDP1 (0.35) | HSD17B10TDP1 | |
| SCHEMBL13326992 | 0.71 | HIF1A (0.43) | ALDH1A1SMN1; SMN2HIF1ALMNAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922419-A | Imidazo [1,2 B] [1,2,4] pyrrolotriazine derivatives as antiparasitic agent | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-04-17 | — | — | CN | disclosed |