Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 11/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.46 |
| ▸ | PPP1CA | P62136 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2822236 | 0.86 | L3MBTL1 (0.52) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL1443064 | 0.76 | L3MBTL1 (0.65) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL1443569 | 0.73 | L3MBTL1 (1.00) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL10270342 | 0.70 | L3MBTL1 (0.65) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL1443058 | 0.69 | L3MBTL1 (0.76) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL1442979 | 0.69 | MEN1 (1.00) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL1442223 | 0.68 | LMNA (0.67) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL1443372 | 0.67 | L3MBTL1 (0.76) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL1443054 | 0.66 | TRPM8 (0.60) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E | |
| SCHEMBL23837648 | 0.66 | TRPM8 (0.73) | L3MBTL1SMN1; SMN2MAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742634-B1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN INC (US) | 2010-10-27 | — | — | EP | claimed |
| US-7560464-B2 | Polycyclic pyrimidines as potassium ion channel modulators | ICAGEN, INC. (US) | 2009-07-14 | — | — | US | claimed |
| EP-1742634-B1 | POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN INC (US) | 2010-10-27 | — | — | EP | disclosed |