Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20453715 | 0.80 | ERN1 (0.47) | ERN1EIF4EMAPTALDH1A1NPSR1 | |
| SCHEMBL5913395 | 0.79 | ERN1 (0.40) | ERN1EIF4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL31647622 | 0.76 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2NPC1HPGD | |
| SCHEMBL18458067 | 0.76 | CASP6 (0.55) | ERN1EIF4ECHEK2 | |
| SCHEMBL4684043 | 0.76 | CASP6 (0.49) | MAPTALDH1A1NPSR1CA2 | |
| SCHEMBL18458311 | 0.75 | MAPT (0.48) | ERN1EIF4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28211106 | 0.74 | ERN1 (0.41) | ERN1EIF4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15741263 | 0.74 | S100A4 (0.47) | ERN1EIF4EMAPTALDH1A1MAOB | |
| SCHEMBL2742575 | 0.73 | MAPT (0.58) | MAPTALDH1A1SMN1; SMN2NPSR1CA2 | |
| SCHEMBL10665444 | 0.73 | TSHR (0.54) | MAPTALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922375-A | Target the antitumoral compounds and its application method of IDH2 mutation | 正大天晴药业集团股份有限公司 | 2018-04-17 | — | — | CN | disclosed |