SCHEMBL28211162

SCHEMBL28211162

CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C=O

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CTSK P43235 6/20 0.56
CTSS P25774 2/20 0.56
CA2 P00918 2/20 0.45
CA1 P00915 1/20 0.45
CA7 P43166 1/20 0.45
CTSL P07711 1/20 0.45
CTSB P07858 1/20 0.45
PSENEN Q9NZ42 1/20 0.44
PREP P48147 1/20 0.43
TRPA1 O75762 1/20 0.42
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
HTT P42858 1/20 0.41
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL963465 0.84 CTSK (0.53) CTSKCTSSCA2CA1CA7
SCHEMBL2058674 0.84 CTSK (0.53) CTSKCTSSCA2CA1CA7
SCHEMBL327825 0.84 CTSK (0.53) CTSKCTSSCA2CA1CA7
SCHEMBL21676408 0.83 CTSK (0.62) CTSKCTSSCA2CA1CA7
SCHEMBL22371978 0.80 CTSK (0.63) CTSKCTSSCA2CA1CA7
SCHEMBL22371979 0.80 CTSK (0.63) CTSKCTSSCA2CA1CA7
SCHEMBL7330229 0.80 CTSK (0.59) CTSKCTSSCA2CA1CA7
SCHEMBL22371977 0.80 CTSK (0.63) CTSKCTSSCA2CA1CA7
SCHEMBL7018649 0.80 CTSK (0.63) CTSKCTSSCA2CA1CA7
SCHEMBL3087516 0.80 CTSK (0.63) CTSKCTSSCA2CA1CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104703991-B Macrocyclic Inhibitors of Flaviviridae Viruses 吉利德科学公司 2018-03-23 CN disclosed