Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.38 |
| ▸ | F2 | P00734 | 6/20 | 0.38 |
| ▸ | CTSS | P25774 | 5/20 | 0.37 |
| ▸ | CTSB | P07858 | 4/20 | 0.37 |
| ▸ | CTSK | P43235 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 4/20 | 0.37 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13456459 | 0.87 | F10 (0.47) | F10F2HPGDPLGPRSS1 | |
| SCHEMBL3805077 | 0.85 | F10 (0.43) | F10F2PLGPRSS1TMPRSS11D | |
| Hydrochloric Acid SCHEMBL2828492 | 0.84 | F10 (0.42) | F10F2PLGPRSS1TMPRSS11D | |
| SCHEMBL5499067 | 0.84 | F10 (0.42) | F10F2PLGPRSS1TMPRSS11D | |
| SCHEMBL2167336 | 0.83 | TMPRSS11D (0.51) | F10F2PLGPRSS1TMPRSS11D | |
| Hydrochloric Acid SCHEMBL6544447 | 0.83 | F10 (0.42) | F10F2PLGPRSS1TMPRSS11D | |
| Hydrochloric Acid SCHEMBL6853389 | 0.83 | TMPRSS11D (0.50) | F10F2PLGPRSS1TMPRSS11D | |
| SCHEMBL13675001 | 0.77 | CA12 (0.40) | F10F2HPGDPLGPRSS1 | |
| SCHEMBL3749302 | 0.76 | MME (0.49) | F10F2HPGDSLC1A3SLC1A2 | |
| SCHEMBL308627 | 0.75 | F2 (0.38) | F10F2PLGPRSS1TMPRSS11D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628965-B1 | HYDROXYAMIDINE AND HYDROXYGUANIDINE COMPOUNDS AS UROKINASE INHIBITORS | WILEX AG (DE) | 2015-07-22 | — | — | EP | disclosed |
| EP-2243774-A1 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | Wilex AG (DE) | 2010-10-27 | — | — | EP | disclosed |
| US-7807681-B2 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | WILEX AG (DE) | 2010-10-05 | — | — | US | disclosed |
| US-20100068272-A1 | HYDROXYAMIDINE AND HYDROXYGUANIDINE COMPOUNDS AS UROKINASE INHIBITORS | WILEX AG (DE) | 2010-03-18 | — | — | US | disclosed |
| US-7608623-B2 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | WILEX AG (DE) | 2009-10-27 | — | — | US | disclosed |
| US-20080261998-A1 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | WILEX AG (DE) | 2008-10-23 | — | — | US | disclosed |
| US-20060142305-A1 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | WILEX AG (DE) | 2006-06-29 | — | — | US | disclosed |
| EP-1628965-A1 | HYDROXYAMIDINE AND HYDROXYGUANIDINE COMPOUNDS AS UROKINASE INHIBITORS | Wilex AG (DE) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004103984-A1 | HYDROXYAMIDINE AND HYDROXYGUANIDINE COMPOUNDS AS UROKINASE INHIBITORS | WILEX AG (DE) | 2004-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142305-A1 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | PLAU, PLAUR, HPN | F10 1217/4885F2 1008/4885CTSS 239/4885 |
| US-20100068272-A1 | HYDROXYAMIDINE AND HYDROXYGUANIDINE COMPOUNDS AS UROKINASE INHIBITORS | PLAU, PLAUR, HPN | F10 1217/4885F2 1008/4885CTSS 239/4885 |
| US-20080261998-A1 | Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors | PLAU, PLAUR, HPN | F10 1217/4885F2 1008/4885CTSS 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.