SCHEMBL28214040

SCHEMBL28214040

COc1ccc(-c2nc(C(=O)O)ccc2Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RPA1 P27694 1/20 0.50
CNR1 P21554 1/20 0.49
ALDH1A1 P00352 3/20 0.49
MAPT P10636 2/20 0.49
HPGD P15428 2/20 0.49
RECQL P46063 1/20 0.49
MCL1 Q07820 2/20 0.46
CTSA P10619 1/20 0.46
PTGDR2 Q9Y5Y4 2/20 0.45
DHODH Q02127 1/20 0.45
CHEK1 O14757 1/20 0.44
KDM4E B2RXH2 5/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
LMNA P02545 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
MEN1 O00255 2/20 0.43
GAA P10253 2/20 0.43
KMT2A Q03164 2/20 0.43
CA1 P00915 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15439943 0.82 MCL1 (0.50) RPA1CNR1ALDH1A1MAPTHPGD
SCHEMBL18582515 0.82 MAPT (0.46) RPA1CNR1ALDH1A1MAPTHPGD
SCHEMBL16698002 0.80 KDM4E (0.52) RPA1CNR1ALDH1A1HPGDDHODH
SCHEMBL25256887 0.80 PPP1CA (0.47) CTSADHODHKDM4ETDP1MEN1
SCHEMBL4455131 0.77 CNR1 (0.67) CNR1ALDH1A1MAPTHPGDRECQL
SCHEMBL2492927 0.75 KMO (0.44) RPA1ALDH1A1MAPTHPGDMCL1
SCHEMBL4630405 0.75 MCL1 (0.60) ALDH1A1MAPTHPGDRECQLMCL1
SCHEMBL30614602 0.75 MCL1 (0.60) ALDH1A1MAPTHPGDRECQLMCL1
SCHEMBL28214042 0.74 CHEK1 (0.52) RPA1ALDH1A1MAPTHPGDMCL1
SCHEMBL21816385 0.74 KDM4E (0.51) ALDH1A1KDM4EL3MBTL1LMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108026042-A Method for being fluorinated compound 美国陶氏益农公司 2018-05-11 CN disclosed