Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.40 |
| ▸ | DRD4 | P21917 | 10/20 | 0.40 |
| ▸ | DRD3 | P35462 | 10/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250269 | 0.90 | SLC18A3 (0.43) | DRD2DRD4DRD3PCSK9SRC | |
| SCHEMBL28598700 | 0.74 | GLA (0.41) | HRH3FLT3MAPK14 | |
| SCHEMBL28601412 | 0.74 | CA12 (0.39) | ACVR1HRH3CYP2D6CYP2C19 | |
| SCHEMBL29094484 | 0.72 | DYRK1A (0.50) | DRD2DRD4DRD3DYRK1AHRH3 | |
| SCHEMBL28611297 | 0.71 | ALPL (0.41) | DYRK1ADYRK1BHRH3CDK9CYP2C19 | |
| SCHEMBL28602234 | 0.71 | ALDH1A1 (0.46) | SRCHRH3ABL1CYP2C19 | |
| SCHEMBL4802183 | 0.71 | HSP90AA1 (0.47) | PCSK9 | |
| SCHEMBL28919027 | 0.70 | ALDH1A1 (0.39) | DRD4HRH3 | |
| SCHEMBL28602153 | 0.70 | DRD2 (0.38) | DRD2DRD4DRD3SRCROCK1 | |
| SCHEMBL28226097 | 0.67 | ESR1 (0.41) | SRCMAP4K4PRKACAKDRCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026094-A | Substituted 4-azaindoles and their use as modulators of the G L UN2B receptor | 詹森药业有限公司 | 2018-05-11 | — | — | CN | claimed |
| CN-108026094-A | Substituted 4-azaindoles and their use as modulators of the G L UN2B receptor | 詹森药业有限公司 | 2018-05-11 | — | — | CN | disclosed |