Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL3304484 | 0.97 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28247967 | 0.95 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL22418373 | 0.95 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL7169119 | 0.95 | LMNA (0.63) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29002744 | 0.92 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28224033 | 0.92 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL3309233 | 0.92 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL4207428 | 0.92 | LMNA (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28465207 | 0.91 | CYP3A4 (0.59) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29092122 | 0.87 | CYP3A4 (0.54) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114891844-A | Method for efficiently pretreating corncobs by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2022-08-12 | — | — | CN | claimed |
| CN-114891844-B | Method for efficiently preprocessing corncob by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2024-05-10 | — | — | CN | disclosed |
| CN-114891844-B | Method for efficiently preprocessing corncob by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2024-05-10 | — | — | CN | disclosed |
| CN-114891844-A | Method for efficiently pretreating corncobs by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-114891844-A | Method for efficiently pretreating corncobs by using ultrasonic-assisted ternary eutectic solvent | 江苏大学 | 2022-08-12 | — | — | CN | disclosed |
| CN-108060444-B | Preparation method of electrodeposited hydroxyapatite in choline chloride ionic liquid | 天津农学院 | 2020-04-10 | — | — | CN | disclosed |
| CN-108060444-A | Preparation method of electrodeposited hydroxyapatite in choline chloride ionic liquid | 天津农学院 | 2018-05-22 | — | — | CN | disclosed |