Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL7169119 | 0.97 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL4207428 | 0.95 | LMNA (0.68) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL3304484 | 0.95 | CYP3A4 (0.68) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL28224033 | 0.95 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL29002744 | 0.95 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL28214932 | 0.92 | CYP3A4 (0.65) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL28247967 | 0.92 | CYP3A4 (0.65) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL22418373 | 0.92 | CYP3A4 (0.65) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL28465207 | 0.88 | CYP3A4 (0.59) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL21693630 | 0.86 | LMNA (0.50) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101826396-B | Electrolyte composition and dye-sensitized solar battery using same | TRIPOD WUXI ELECTRONIC CO LTD | 2012-07-11 | — | — | CN | disclosed |
| CN-101826396-A | Electrolyte composition and dye-sensitized solar battery using same | TRIPOD TECH WUXI ELECTRONICS LTD | 2010-09-08 | — | — | CN | disclosed |
| US-20100101644-A1 | ELECTROLYTE COMPOSITION AND DYE-SENSITIZED SOLAR CELL (DSSC) COMPRISING THE SAME | TRIPOD TECHNOLOGY CORPORATION (TW) | 2010-04-29 | — | — | US | disclosed |