Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL22418373 | 0.97 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28247967 | 0.97 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28214932 | 0.97 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL7169119 | 0.97 | LMNA (0.63) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28224033 | 0.95 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL3309233 | 0.95 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL4207428 | 0.95 | LMNA (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29002744 | 0.95 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28465207 | 0.93 | CYP3A4 (0.59) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28838083 | 0.89 | CYP3A4 (0.54) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 320 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118197817-A | CNTs-MXenes composite material and preparation method and application thereof | 中国科学院宁波材料技术与工程研究所 | 2024-06-14 | — | — | CN | claimed |
| CN-118185362-A | Water mist infrared stealth solution and preparation method thereof | 江苏鸿源动力科技有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-118166055-A | Crayfish shell ACE (angiotensin converting enzyme) inhibitory peptide and preparation method and application thereof | 湖北工业大学 | 2024-06-11 | — | — | CN | claimed |
| CN-118126214-A | Method for curing UV-LED by capsanthin/iodonium salt photoinitiation system | 南京林业大学 | 2024-06-04 | — | — | CN | claimed |
| CN-118063815-A | Preparation method and application of functional composite film containing lignin extract | 中山大学附属第三医院 | 2024-05-24 | — | — | CN | claimed |
| CN-114164244-B | Method for preparing hesperetin-7-O-glucoside and hesperetin | 华南理工大学 | 2024-03-01 | — | — | CN | claimed |
| CN-117384303-A | Preparation method of high-stability oxidized regenerated bean dreg cellulose nanocrystalline | 中国农业科学院农产品加工研究所 | 2024-01-12 | — | — | CN | claimed |
| CN-117258767-A | Novel psychoactive substance adsorbent and application thereof | 西南政法大学 | 2023-12-22 | — | — | CN | claimed |
| CN-114411176-B | Photoelectrocatalysis preparation H 2 O 2 Device and application thereof | 太原师范学院 | 2023-10-27 | — | — | CN | claimed |
| CN-116904524-A | Method for enzyme-catalyzed hydrolysis of ester substances by microfluidic three-liquid phase system | 华南理工大学 | 2023-10-20 | — | — | CN | claimed |
| CN-108048421-A | The method that transfructosylase catalytic efficiency and stability are improved using choline eutectic solvent | 天津科技大学 | 2018-05-18 | — | — | CN | claimed |
| CN-104357526-B | The method for preparing cholestenone using conversion of resting cells using eutectic as chaotropic agent | 天津科技大学 | 2018-05-18 | — | — | CN | claimed |
| CN-107970157-A | A kind of preparation method of the crease-resistant plant essence containing natural lemon acid | 唐雪平 | 2018-05-01 | — | — | CN | claimed |
| CN-107898700-A | A kind of preparation method of the anti-aging nanometer lip gloss containing vine polyphenol | 唐雪平 | 2018-04-13 | — | — | CN | claimed |
| CN-107854366-A | A kind of preparation method of natural fruit pigment used for cosmetic | 林燕 | 2018-03-30 | — | — | CN | claimed |
| CN-107737096-A | A kind of preparation method of pearl whitening additive used for cosmetic | 林燕 | 2018-02-27 | — | — | CN | claimed |
| CN-107714629-A | A kind of preparation method of the cosmetic pencil pen oil containing butter berry extract | 林燕 | 2018-02-23 | — | — | CN | claimed |
| CN-107216718-A | A kind of preparation method of temperature-control discoloring ink | 厦门市诚安毅科技有限公司 | 2017-09-29 | — | — | CN | claimed |
| CN-106749805-A | A kind of atom transfer radical polymerization method of utilization low temperature eutectic effect | 华中科技大学 | 2017-05-31 | — | — | CN | claimed |
| CN-105861571-A | Method for catalyzing asymmetric hydrolysis of 1,2-epoxyoctane by soybean epoxide hydrolase | 华南理工大学 | 2016-08-17 | — | — | CN | claimed |