Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 4/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821522 | 1.00 | KCNK3 (0.38) | KCNK3KCNK9CXCR3KDM4EALDH1A1 | |
| SCHEMBL2821318 | 0.91 | KCNK3 (0.37) | KCNK3KCNK9CXCR3KDM4EALDH1A1 | |
| SCHEMBL2821317 | 0.91 | KCNK3 (0.37) | KCNK3KCNK9CXCR3KDM4EALDH1A1 | |
| SCHEMBL2822006 | 0.82 | CNR2 (0.34) | KCNK3KCNK9KDM4EALDH1A1GAA | |
| SCHEMBL2822010 | 0.82 | CNR2 (0.34) | KCNK3KCNK9KDM4EALDH1A1GAA | |
| SCHEMBL2819037 | 0.81 | LMNA (0.39) | ALDH1A1MAPTPDE4APOLB | |
| SCHEMBL2819041 | 0.81 | LMNA (0.39) | ALDH1A1MAPTPDE4APOLB | |
| SCHEMBL2819042 | 0.81 | MDM2 (0.34) | GAAMAPTPDE4A | |
| SCHEMBL2819045 | 0.81 | MDM2 (0.34) | GAAMAPTPDE4A | |
| SCHEMBL2847363 | 0.79 | KCNK3 (0.38) | KCNK3KCNK9CXCR3MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292254-A1 | Fused Pyrimidine Derivatives as Trpv3 Modulators | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292254-A1 | Fused Pyrimidine Derivatives as Trpv3 Modulators | TRPV3, TRPV1, TRPV5 | KCNK3 121/4885KCNK9 483/4885CXCR3 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.