Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821849 | 0.84 | GAA (0.46) | GAAMAPTNPSR1NR1H2NR1H3 | |
| SCHEMBL2825609 | 0.81 | SMN1; SMN2 (0.44) | GAAMAPTNPSR1NR1H2NR1H3 | |
| SCHEMBL2821858 | 0.81 | MAPT (0.68) | GAAMAPTNPSR1SMN1; SMN2TACR1 | |
| SCHEMBL1125943 | 0.81 | GAA (0.64) | GAAMAPTNPSR1NR1H2NR1H3 | |
| SCHEMBL6024428 | 0.81 | ESR1 (0.51) | GAAMAPTNPSR1NR1H2NR1H3 | |
| SCHEMBL2824028 | 0.79 | FABP3 (0.43) | GAAMAPTNPSR1NR1H2NR1H3 | |
| SCHEMBL2825677 | 0.78 | FABP3 (0.45) | GAAMAPTNPSR1SMN1; SMN2TACR1 | |
| SCHEMBL2821880 | 0.78 | FABP3 (0.45) | GAAMAPTNPSR1SMN1; SMN2TACR1 | |
| SCHEMBL2826514 | 0.77 | TACR1 (0.42) | GAAMAPTNPSR1SMN1; SMN2TACR1 | |
| SCHEMBL2823196 | 0.77 | GAA (0.40) | GAAMAPTNPSR1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |