SCHEMBL28215657

SCHEMBL28215657

Cc1ccc(-n2cc(C3CCN(OC(=O)C(C)(C)C)CC3)nn2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 0.46
NPC1 O15118 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
KMT2A Q03164 1/20 0.43
CA1 P00915 3/20 0.43
CA2 P00918 3/20 0.43
CA9 Q16790 3/20 0.43
CA12 O43570 2/20 0.43
ACKR3 P25106 5/20 0.41
NOTUM Q6P988 1/20 0.41
GRM5 P41594 2/20 0.39
GRM1 Q13255 2/20 0.39
PTGS2 P35354 2/20 0.39
GPR119 Q8TDV5 2/20 0.39
RXRA P19793 1/20 0.39
GRIN1 Q05586 1/20 0.39
GRIN2B Q13224 1/20 0.39
PTGS1 P23219 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27666686 0.90 NPC1 (0.54) MIFNPC1CYP1A2CYP2C9CYP2C19
SCHEMBL20135095 0.83 GPR119 (0.58) KMT2AGRM5GRM1GPR119
SCHEMBL28080036 0.74 LMNA (0.40) GPR119POLB
SCHEMBL31563796 0.73 GRM1 (0.61) KMT2AGRM5GRM1GPR119POLB
SCHEMBL8614193 0.73 GRM1 (0.60) GRM5GRM1GPR119POLB
SCHEMBL20134969 0.72 MIF (0.54) MIFCA1CA2CA9CA12
Hydrochloric Acid SCHEMBL28215591 0.71 MIF (0.52) MIFCA1CA2CA9CA12
SCHEMBL28812528 0.71 TRPC6 (0.54)
SCHEMBL27628276 0.70 HTT (0.35) KMT2A
SCHEMBL28328550 0.69 EPHX2 (0.46) KMT2AGPR119GRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922347-A New imide derivative and its purposes as medicine 田边三菱制药株式会社 2018-04-17 CN disclosed